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Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

Acute pancreatitis is characterized by premature intracellular protease activation and infiltration of inflammatory cells, mainly neutrophil granulocytes and macrophages, into the organ. The lysosomal proteases cathepsin B, D, and L have been identified as regulators of early zymogen activation and...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: John, Daniel S., Aschenbach, Julia, Krüger, Burkhard, Sendler, Matthias, Weiss, F. Ulrich, Mayerle, Julia, Lerch, Markus M., Aghdassi, Ali A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333881/
https://ncbi.nlm.nih.gov/pubmed/30455353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004376
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