Targeting GRP78 to enhance melanoma cell death

Targeting endoplasmic-reticulum (ER) stress-induced apoptosis may offer an alternative therapeutic strategy for metastatic melanoma. Fenretinide and bortezomib induce apoptosis of melanoma cells but their efficacy may be hindered by the unfolded protein response (UPR) which promotes survival by amel...

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Main Authors: Martin, Shaun, Hill, David S., Paton, James C., Paton, Adrienne W., Birch-Machin, Mark A., Lovat, Penny E., Redfern, Chris P.F.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941718/
https://ncbi.nlm.nih.gov/pubmed/20546536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2010.00731.x
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