Increasing Melanoma Cell Death Using Inhibitors of Protein Disulphide Isomerases to Abrogate Survival Responses to Endoplasmic Reticulum Stress

Exploiting vulnerabilities in the intracellular signalling pathways of tumor cells is a key strategy for the development of new drugs. The activation of cellular stress responses mediated by the endoplasmic reticulum (ER) allows cancer cells to survive outside their normal environment. Many proteins...

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Main Authors: Lovat, Penny E., Corazzari, Marco, Armstrong, Jane L., Martin, Shaun, Pagliarini, Vittoria, Hill, David, Brown, Anna M., Piacentini, Mauro, Birch-Machin, Mark A., Redfern, Christopher P. F.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917766/
https://ncbi.nlm.nih.gov/pubmed/18593938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0035
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