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Chk1 promotes replication fork progression by controlling replication initiation
DNA replication starts at initiation sites termed replication origins. Metazoan cells contain many more potential origins than are activated (fired) during each S phase. Origin activation is controlled by the ATR checkpoint kinase and its downstream effector kinase Chk1, which suppresses origin firi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941317/ https://ncbi.nlm.nih.gov/pubmed/20805465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005031107 |
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