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Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase

Chk1 protein kinase maintains replication fork stability in metazoan cells in response to DNA damage and DNA replication inhibitors. Here, we have employed DNA fiber labeling to quantify, for the first time, the extent to which Chk1 maintains global replication fork rates during normal vertebrate S...

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Detalhes bibliográficos
Main Authors: Petermann, Eva, Maya-Mendoza, Apolinar, Zachos, George, Gillespie, David A. F., Jackson, Dean A., Caldecott, Keith W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446959/
https://ncbi.nlm.nih.gov/pubmed/16581803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.3319-3326.2006
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