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Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase

Chk1 protein kinase maintains replication fork stability in metazoan cells in response to DNA damage and DNA replication inhibitors. Here, we have employed DNA fiber labeling to quantify, for the first time, the extent to which Chk1 maintains global replication fork rates during normal vertebrate S...

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Autors principals: Petermann, Eva, Maya-Mendoza, Apolinar, Zachos, George, Gillespie, David A. F., Jackson, Dean A., Caldecott, Keith W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446959/
https://ncbi.nlm.nih.gov/pubmed/16581803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.3319-3326.2006
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