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OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity

KREPA4, also called MP24, is an essential mitochondrial guide RNA (gRNA)-binding protein with a preference for the 3′ oligo(U) tail in trypanosomes. Structural prediction and compositional analysis of KREPA4 have identified a conserved OB (oligonucleotide/oligosaccharide-binding)-fold at the C-termi...

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Bibliographische Detailangaben
Hauptverfasser: Kala, Smriti, Salavati, Reza
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941104/
https://ncbi.nlm.nih.gov/pubmed/20713467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2124610
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