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OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity
KREPA4, also called MP24, is an essential mitochondrial guide RNA (gRNA)-binding protein with a preference for the 3′ oligo(U) tail in trypanosomes. Structural prediction and compositional analysis of KREPA4 have identified a conserved OB (oligonucleotide/oligosaccharide-binding)-fold at the C-termi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941104/ https://ncbi.nlm.nih.gov/pubmed/20713467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2124610 |
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