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TG101209, a novel JAK2 inhibitor, has significant in-vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells
Interaction of myeloma cells with the bone marrow microenvironment is mediated in large part through different cytokines, especially VEGF and IL6. These cytokines, especially IL6, leads to up-regulation of the JAK/STAT pathway in myeloma cell, contributing to increased proliferation, decreased apopt...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940994/ https://ncbi.nlm.nih.gov/pubmed/20652971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21785 |
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