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SMC-Specific IGF-1 Overexpression in Apoe(−/−) Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of Plaque Stability

OBJECTIVE: Growth factors may play a permissive role in atherosclerosis initiation and progression, in part via their promotion of VSMC accumulation in plaques. However, unstable human plaques often have a relative paucity of VSMC which has been suggested to contribute to plaque rupture and/or erosi...

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Detalhes bibliográficos
Main Authors: Shai, Shaw-Yung, Sukhanov, Sergiy, Higashi, Yusuke, Vaughn, Charlotte, Kelly, James, Delafontaine, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940990/
https://ncbi.nlm.nih.gov/pubmed/20671230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.210831
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