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Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity
IMPORTANCE OF THE FIELD: Microsomal cytochrome P450s are critical for drug metabolism and toxicity. Recent studies show that these CYPs are also present in the mitochondrial compartment of human and rodent tissues. Mitochondrial CYP1A1 and 2E1 show both overlapping and distinct metabolic activities...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940958/ https://ncbi.nlm.nih.gov/pubmed/20629582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.2010.503955 |
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