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The Neutrophil Elastase Inhibitor, Elafin, Triggers Rb-Mediated Growth Arrest and Caspase-Dependent Apoptosis in Breast Cancer

Elafin, an endogenous inhibitor of neutrophil elastase, is expressed in human mammary epithelial cells, but is transcriptionally downregulated in breast cancer cells. We hypothesized that elafin may exert a tumor suppressive activity in the context of breast cancer. In this study, we demonstrate tha...

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Bibliografiske detaljer
Main Authors: Caruso, Joseph A., Hunt, Kelly K., Keyomarsi, Khandan
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940941/
https://ncbi.nlm.nih.gov/pubmed/20823156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1547
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