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The Neutrophil Elastase Inhibitor, Elafin, Triggers Rb-Mediated Growth Arrest and Caspase-Dependent Apoptosis in Breast Cancer
Elafin, an endogenous inhibitor of neutrophil elastase, is expressed in human mammary epithelial cells, but is transcriptionally downregulated in breast cancer cells. We hypothesized that elafin may exert a tumor suppressive activity in the context of breast cancer. In this study, we demonstrate tha...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940941/ https://ncbi.nlm.nih.gov/pubmed/20823156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1547 |
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