Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

BACKGROUND: Mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes of Plasmodium falciparum are associated with resistance to anti-folate drugs, most notably sulphadoxine-pyrimethamine (SP). Molecular studies document the prevalence of these mutations in parasite p...

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Autori principali: Sridaran, Sankar, McClintock, Shannon K, Syphard, Luke M, Herman, Karen M, Barnwell, John W, Udhayakumar, Venkatachalam
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940896/
https://ncbi.nlm.nih.gov/pubmed/20799995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-9-247
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