Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia

Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for the treatment of uncomplicated falciparum mala...

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Udgivet i:PLoS One
Main Authors: Tessema, Sofonias K., Kassa, Moges, Kebede, Amha, Mohammed, Hussein, Leta, Gemechu Tadesse, Woyessa, Adugna, Guma, Geremew Tasew, Petros, Beyene
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591967/
https://ncbi.nlm.nih.gov/pubmed/26431464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126943
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