The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

Oxidative stress and mitochondrial dysfunction play an important role in acetaminophen (APAP)-induced hepatocyte cell death. However, exact mechanisms involved in the process are controversial, in part, because of the disparity in findings between in vitro and in vivo studies. A major difference in...

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Bibliografiske detaljer
Main Authors: Yan, Hui-Min, Ramachandran, Anup, Bajt, Mary Lynn, Lemasters, John J., Jaeschke, Hartmut
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Systems Toxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940407/
https://ncbi.nlm.nih.gov/pubmed/20616211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq208
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