Impact of Dendritic Spine Preservation in Medium Spiny Neurons on Dopamine Graft Efficacy and the Expression of Dyskinesias in Parkinsonian Rats

Dopamine deficiency associated with Parkinson’s disease (PD) results in numerous changes in striatal transmitter function and neuron morphology. Specifically, there is marked atrophy of dendrites and dendritic spines on striatal medium spiny neurons (MSN), primary targets of inputs from nigral dopam...

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Detalhes bibliográficos
Main Authors: Soderstrom, Katherine E., O’Malley, Jennifer A., Levine, Nathan D., Sortwell, Caryl E., Collier, Timothy J., Steece-Collier, Kathy
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940228/
https://ncbi.nlm.nih.gov/pubmed/20105237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07077.x
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