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Dual inhibition of both the EGFR and erbB2 effectively inhibits promotion of skin tumors during two-stage carcinogenesis

The erbB family of receptor tyrosine kinases are known to play important roles in both normal epithelial development and epithelial neoplasia. Considerable evidence also suggests that signaling through the EGFR plays an important role in multistage skin carcinogenesis in mice; however, less is known...

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Hlavní autoři: Kiguchi, Kaoru, Kitamura, Takuya, Moore, Tricia, Rumi, Mohammad, Chang, Hsiang-Chun, Treece, Devon, Ruffino, Lynnsie, Connolly, Kevin, DiGiovanni, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940063/
https://ncbi.nlm.nih.gov/pubmed/20682802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0010
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