Synthesis, Structure-Activity Relationship, & Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

We have previously shown that a 'reversed chloroquine (RCQ)' molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum (Burgess, S. J.; Selzer, A.; Kelly, J. X.; Smilkstein, M. J.; Riscoe, M. K.; Peyton, D. H...

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Main Authors: Burgess, Steven J., Kelly, Jane X., Shomloo, Shawheen, Wittlin, Sergio, Brun, Reto, Liebmann, Katherine, Peyton, David H.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939913/
https://ncbi.nlm.nih.gov/pubmed/20684562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1006484
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