On the molecular mechanism of chloroquine's antimalarial action.
Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of [...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38150/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11865 |
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