On the molecular mechanism of chloroquine's antimalarial action.
Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of [...
保存先:
| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1996
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38150/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11865 |
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