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Reversal Agent and Linker Variants of Reversed Chloroquines: Activities against Plasmodium falciparum

We have shown that “Reversed Chloroquine molecules” constructed from chloroquine-like and resistance “reversal agent”-like cores, can be powerful drugs against malaria (J. Med. Chem., 2006, 49, 5623–5). Several Reversed Chloroquines are now presented which probe parameters governing the activities a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Andrews, Simeon, Burgess, Steven J., Skaalrud, Deborah, Kelly, Jane Xu, Peyton, David H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929814/
https://ncbi.nlm.nih.gov/pubmed/20088608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900972u
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