A Chloroquine-like Molecule Designed to Reverse Resistance in Plasmodium falciparum

A class of hybrid molecules which we term ‘reversed chloroquines’ (RCQs) was designed, and a prototype molecule, N′-(7-chloroquinolin-4-yl)-N-[3-(10,11-dihydrodibenzo[b,f]azepin-5-yl)propyl]-N-methylpropane-1,3-diamine (1), was synthesized and tested against both chloroquine-sensitive and chloroquin...

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Bibliografiska uppgifter
Huvudupphovsmän: Burgess, Steven J., Selzer, Audrey, Kelly, Jane Xu, Smilkstein, Martin J., Riscoe, Michael K., Peyton, David H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2215738/
https://ncbi.nlm.nih.gov/pubmed/16942036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060399n
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