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A Chloroquine-like Molecule Designed to Reverse Resistance in Plasmodium falciparum
A class of hybrid molecules which we term ‘reversed chloroquines’ (RCQs) was designed, and a prototype molecule, N′-(7-chloroquinolin-4-yl)-N-[3-(10,11-dihydrodibenzo[b,f]azepin-5-yl)propyl]-N-methylpropane-1,3-diamine (1), was synthesized and tested against both chloroquine-sensitive and chloroquin...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2215738/ https://ncbi.nlm.nih.gov/pubmed/16942036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060399n |
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