Modulation of Cell Signaling Networks after CTLA4 Blockade in Patients with Metastatic Melanoma

BACKGROUND: The effects on cell signalling networks upon blockade of cytotoxic T lymphocyte-associated antigen-4 (CTLA4) using the monoclonal antibody tremelimumab were studied in peripheral blood mononuclear cell (PBMC) samples from patients with metastatic melanoma. METHODOLOGY/PRINCIPAL: Findings...

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Hauptverfasser: Comin-Anduix, Begoña, Sazegar, Hooman, Chodon, Thinle, Matsunaga, Douglas, Jalil, Jason, von Euw, Erika, Escuin-Ordinas, Helena, Balderas, Robert, Chmielowski, Bartosz, Gomez-Navarro, Jesus, Koya, Richard C., Ribas, Antoni
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939876/
https://ncbi.nlm.nih.gov/pubmed/20856802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012711
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