Identification of common predictive markers of in vitro response to the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines

Selumetinib (AZD6244; ARRY-142886) is a tight-binding, uncompetitive inhibitor of MEK1/2 currently in clinical development. We evaluated the effects of selumetinib in 31 human breast cancer cell lines and 43 human non-small cell lung cancer (NSCLC) cell lines to identify characteristics correlating...

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Main Authors: Garon, Edward B., Finn, Richard S., Hosmer, Wylie, Dering, Judy, Ginther, Charles, Adhami, Shahriar, Kamranpour, Naeimeh, Pitts, Sharon, Desai, Amrita, Elashoff, David, French, Tim, Smith, Paul, Slamon, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939826/
https://ncbi.nlm.nih.gov/pubmed/20587667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0037
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