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Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine

We report the synthesis, structure, and pairing properties in DNA of an isostere for deoxyadenosine which lacks all hydrogen-bonding functionality on the Watson–Crick pairing edge. A deoxyribo-nucleoside derivative of 4-methylbenzimidazole (1), which was recently shown to be inserted into DNA by Kle...

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Main Authors: Guckian, Kevin M., Morales, Juan C., Kool, Eric T.
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939748/
https://ncbi.nlm.nih.gov/pubmed/20852720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo9805100
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