Pharmacological Inhibition of BMK1 Suppresses Tumor Growth Through PML

BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited its tumor-suppressor function through phosphorylation. Furthermore, activated BMK1 notably inhibited PML-depe...

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Detalhes bibliográficos
Main Authors: Yang, Qingkai, Deng, Xianming, Lu, Bingwen, Cameron, Michael, Fearns, Colleen, Patricelli, Matthew P., Yates, John R., Gray, Nathanael S., Lee, Jiing-Dwan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939729/
https://ncbi.nlm.nih.gov/pubmed/20832753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.08.008
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