Pharmacological Inhibition of BMK1 Suppresses Tumor Growth Through PML

BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited its tumor-suppressor function through phosphorylation. Furthermore, activated BMK1 notably inhibited PML-depe...

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Bibliografske podrobnosti
Main Authors: Yang, Qingkai, Deng, Xianming, Lu, Bingwen, Cameron, Michael, Fearns, Colleen, Patricelli, Matthew P., Yates, John R., Gray, Nathanael S., Lee, Jiing-Dwan
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939729/
https://ncbi.nlm.nih.gov/pubmed/20832753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.08.008
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