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BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction
Promyelocytic leukemia protein (PML) modulates the p53 tumor suppressor through its interaction with p53 and MDM2. We found that activated BMK1 preferentially associates with PML isoform IV and disrupts PML-MDM2 interaction. Doxorubicin, a common chemotherapeutic agent, is known to promote PML-media...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493705/ https://ncbi.nlm.nih.gov/pubmed/22869143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.332 |
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