TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation

Stress-induced activation of p53 is an essential cellular response to prevent aberrant cell proliferation and cancer development. The ubiquitin ligase MDM2 promotes p53 degradation and limits the duration of p53 activation. It remains unclear, however, how p53 persistently escapes MDM2-mediated nega...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Maeda, Ryo, Tamashiro, Hiroyuki, Takano, Kazunori, Takahashi, Hiro, Suzuki, Hidefumi, Saito, Shinta, Kojima, Waka, Adachi, Noritaka, Ura, Kiyoe, Endo, Takeshi, Tamura, Taka-aki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336156/
https://ncbi.nlm.nih.gov/pubmed/28082682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763318
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