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TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation

Stress-induced activation of p53 is an essential cellular response to prevent aberrant cell proliferation and cancer development. The ubiquitin ligase MDM2 promotes p53 degradation and limits the duration of p53 activation. It remains unclear, however, how p53 persistently escapes MDM2-mediated nega...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Maeda, Ryo, Tamashiro, Hiroyuki, Takano, Kazunori, Takahashi, Hiro, Suzuki, Hidefumi, Saito, Shinta, Kojima, Waka, Adachi, Noritaka, Ura, Kiyoe, Endo, Takeshi, Tamura, Taka-aki
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336156/
https://ncbi.nlm.nih.gov/pubmed/28082682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763318
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