Long-Acting Phosphodiesterase-5 Inhibitor Tadalafil Attenuates Doxorubicin-Induced Cardiomyopathy without Interfering with Chemotherapeutic Effect

Doxorubicin (DOX) is one of the most effective anticancer drugs. However, its cardiotoxicity remains a clinical concern that severely restricts its therapeutic usage. We designed this study to investigate whether tadalafil, a long-acting phosphodiesterase-5 (PDE-5) inhibitor, protects against DOX-in...

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Bibliographische Detailangaben
Hauptverfasser: Koka, Saisudha, Das, Anindita, Zhu, Shu-Guang, Durrant, David, Xi, Lei, Kukreja, Rakesh C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2010
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939673/
https://ncbi.nlm.nih.gov/pubmed/20543097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.170191
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