Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice: POTENTIAL ROLE OF ATTENUATED OXIDATIVE STRESS AND ALTERED CONTRACTILE PROTEIN EXPRESSION

Elevated mammalian target of rapamycin (mTOR) signaling contributes to the pathogenesis of diabetes, with increased morbidity and mortality, mainly because of cardiovascular complications. Because mTOR inhibition with rapamycin protects against ischemia/reperfusion injury, we hypothesized that rapam...

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Bibliografski detalji
Glavni autori: Das, Anindita, Durrant, David, Koka, Saisudha, Salloum, Fadi N., Xi, Lei, Kukreja, Rakesh C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924280/
https://ncbi.nlm.nih.gov/pubmed/24371138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521062
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