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Intracisternal Nor-Binaltorphimine Distinguishes Central and Peripheral κ-Opioid Antinociception in Rhesus Monkeys

Systemic administration of nor-binaltorphimine (nor-BNI) produces a long-lasting κ-opioid receptor (κOR) antagonism and has κ(1)-selectivity in nonhuman primates. The aim of this study was to establish the pharmacological basis of central κOR antagonism in rhesus monkeys (Macaca mulatta). After intr...

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Autors principals: Ko, M. C. Holden, Johnson, Mark D., Butelman, Eduardo R., Willmont, Kurt J., Mosberg, Henry I., Woods, James H.
Format: Artigo
Idioma:Inglês
Publicat: 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939326/
https://ncbi.nlm.nih.gov/pubmed/10565831
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