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Activation of Peripheral κ Opioid Receptors Inhibits Capsaicin-Induced Thermal Nociception in Rhesus Monkeys
8-Methyl-N-vanillyl-6-nonenamide (capsaicin) was locally applied in the tail of rhesus monkeys to evoke a nociceptive response, thermal allodynia, which was manifested as reduced tail-withdrawal latencies in normally innocuous 46°C water. Coadministration of three κ opioid ligands, U50,488 (3.2–100...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865196/ https://ncbi.nlm.nih.gov/pubmed/10087027 |
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