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PARP-1 Regulates Chromatin Structure and Transcription Through a KDM5B-Dependent Pathway
PARP-1 is an abundant nuclear enzyme that regulates gene expression, although the underlying mechanisms are unclear. We examined the interplay between PARP-1, histone 3 lysine 4 trimethylation (H3K4me3), and linker histone H1 in the chromatin-dependent control of transcription. We show that PARP-1 i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939044/ https://ncbi.nlm.nih.gov/pubmed/20832725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.08.014 |
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