KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription

Although regulation of histone methylation is believed to contribute to embryonic stem cell (ESC) self-renewal, the mechanisms remain obscure. We show here that the histone H3 trimethyl lysine 4 (H3K4me3) demethylase, KDM5B, is a downstream Nanog target and critical for ESC self-renewal. Although KD...

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Hlavní autoři: Xie, Liangqi, Pelz, Carl, Wang, Wensi, Bashar, Amir, Varlamova, Olga, Shadle, Sean, Impey, Soren
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102288/
https://ncbi.nlm.nih.gov/pubmed/21448134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.91
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