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KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription
Although regulation of histone methylation is believed to contribute to embryonic stem cell (ESC) self-renewal, the mechanisms remain obscure. We show here that the histone H3 trimethyl lysine 4 (H3K4me3) demethylase, KDM5B, is a downstream Nanog target and critical for ESC self-renewal. Although KD...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102288/ https://ncbi.nlm.nih.gov/pubmed/21448134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.91 |
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