High Resolution Mapping of Protein Sequence–Function Relationships

We present a large-scale approach to investigate the functional consequences of sequence variation in a protein. The approach entails the display of hundreds of thousands of protein variants, moderate selection for activity, and high throughput DNA sequencing to quantify the performance of each vari...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fowler, Douglas M., Araya, Carlos L., Fleishman, Sarel J., Kellogg, Elizabeth H., Stephany, Jason J., Baker, David, Fields, Stanley
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938879/
https://ncbi.nlm.nih.gov/pubmed/20711194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1492
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