High Resolution Mapping of Protein Sequence–Function Relationships

We present a large-scale approach to investigate the functional consequences of sequence variation in a protein. The approach entails the display of hundreds of thousands of protein variants, moderate selection for activity, and high throughput DNA sequencing to quantify the performance of each vari...

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Bibliografiske detaljer
Main Authors: Fowler, Douglas M., Araya, Carlos L., Fleishman, Sarel J., Kellogg, Elizabeth H., Stephany, Jason J., Baker, David, Fields, Stanley
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938879/
https://ncbi.nlm.nih.gov/pubmed/20711194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1492
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