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Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression
Defining the molecular mechanisms underpinning fetal (γ) globin gene silencing may provide strategies for reactivation of γ-gene expression, a major therapeutic objective in patients with β-thalassemia and sickle cell disease (SCD). We have previously demonstrated that symmetric methylation of histo...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938845/ https://ncbi.nlm.nih.gov/pubmed/20495075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-251116 |
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