The role of WDR5 in silencing human fetal globin gene expression

BACKGROUND: Histone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been...

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Detalhes bibliográficos
Main Authors: Xu, Zhen, He, Yinghong, Ju, Junyi, Rank, Gerhard, Cerruti, Loretta, Ma, Chi, Simpson, Richard J., Moritz, Robert L., Jane, Stephen M., Zhao, Quan
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487434/
https://ncbi.nlm.nih.gov/pubmed/22689669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.061937
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