The role of WDR5 in silencing human fetal globin gene expression

BACKGROUND: Histone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in human globin gene regulation has not yet been...

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Autores principales: Xu, Zhen, He, Yinghong, Ju, Junyi, Rank, Gerhard, Cerruti, Loretta, Ma, Chi, Simpson, Richard J., Moritz, Robert L., Jane, Stephen M., Zhao, Quan
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2012
Materias:
Original Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487434/
https://ncbi.nlm.nih.gov/pubmed/22689669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.061937
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