A carregar...

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

Defining the molecular mechanisms underpinning fetal (γ) globin gene silencing may provide strategies for reactivation of γ-gene expression, a major therapeutic objective in patients with β-thalassemia and sickle cell disease (SCD). We have previously demonstrated that symmetric methylation of histo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Rank, Gerhard, Cerruti, Loretta, Simpson, Richard J., Moritz, Robert L., Jane, Stephen M., Zhao, Quan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938845/
https://ncbi.nlm.nih.gov/pubmed/20495075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-251116
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!