miR-192 Mediates TGF-β/Smad3-Driven Renal Fibrosis

TGF-β/Smad3 promotes renal fibrosis, but the mechanisms that regulate profibrotic genes remain unclear. We hypothesized that miR-192, a microRNA expressed in the kidney may mediate renal fibrosis in a Smad3-dependent manner. Microarray and real-time PCR demonstrated a tight association between upreg...

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Autori principali: Chung, Arthur C.K., Huang, Xiao R., Meng, Xiaoming, Lan, Hui Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2010
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938591/
https://ncbi.nlm.nih.gov/pubmed/20488955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010020134
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