SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

AIMS: Endothelial activation, macrophage infiltration, and foam cell formation are pivotal steps in atherogenesis. Our aim in this study was to analyse the role of SIRT1, a class III deacetylase with important metabolic functions, in plaque macrophages and atherogenesis. METHODS AND RESULTS: Using p...

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Bibliografische gegevens
Hoofdauteurs: Stein, Sokrates, Lohmann, Christine, Schäfer, Nicola, Hofmann, Janin, Rohrer, Lucia, Besler, Christian, Rothgiesser, Karin M., Becher, Burkhard, Hottiger, Michael O., Borén, Jan, McBurney, Michael W., Landmesser, Ulf, Lüscher, Thomas F., Matter, Christian M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2010
Onderwerpen:
Basic Science
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938465/
https://ncbi.nlm.nih.gov/pubmed/20418343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehq107
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