SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension of lifespan. In the vasculature,SIRT1 gain-of...

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Detalhes bibliográficos
Main Authors: Stein, Sokrates, Schäfer, Nicola, Breitenstein, Alexander, Besler, Christian, Winnik, Stephan, Lohmann, Christine, Heinrich, Kathrin, Brokopp, Chad E., Handschin, Christoph, Landmesser, Ulf, Tanner, Felix C., Lüscher, Thomas F., Matter, Christian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919255/
https://ncbi.nlm.nih.gov/pubmed/20606253
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