Road blocks on paleogenomes—polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA

Although the last few years have seen great progress in DNA sequence retrieval from fossil specimens, some of the characteristics of ancient DNA remain poorly understood. This is particularly true for blocking lesions, i.e. chemical alterations that cannot be bypassed by DNA polymerases and thus pre...

Full description

Saved in:
Bibliographic Details
Main Authors: Heyn, Patricia, Stenzel, Udo, Briggs, Adrian W., Kircher, Martin, Hofreiter, Michael, Meyer, Matthias
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938203/
https://ncbi.nlm.nih.gov/pubmed/20587499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq572
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items