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A Nuclease-Resistant RNA Aptamer Specifically Inhibits Angiopoietin-1-Mediated Tie2 Activation and Function
Tie2 is a receptor tyrosine kinase that is expressed predominantly in the endothelium and that plays key roles in both physiological and pathological angiogenesis. The ligands for Tie2, the angiopoietins (Ang), perform opposing functions in vascular maintenance and angiogenesis; Ang1 regulates vascu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938016/ https://ncbi.nlm.nih.gov/pubmed/19037734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-008-9122-4 |
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