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Aptamers as Therapeutics

Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by exponential enrichment (SELEX). Aptamers undergo extensive pharmacological revision, which alters affinity, specificity, and therapeutic half-life, ta...

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Bibliografiska uppgifter
I publikationen:Annu Rev Pharmacol Toxicol
Huvudupphovsmän: Nimjee, Shahid M., White, Rebekah R., Becker, Richard C., Sullenger, Bruce A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035745/
https://ncbi.nlm.nih.gov/pubmed/28061688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010716-104558
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