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Aptamers as Therapeutics

Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by exponential enrichment (SELEX). Aptamers undergo extensive pharmacological revision, which alters affinity, specificity, and therapeutic half-life, ta...

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書目詳細資料
發表在:Annu Rev Pharmacol Toxicol
Main Authors: Nimjee, Shahid M., White, Rebekah R., Becker, Richard C., Sullenger, Bruce A.
格式: Artigo
語言:Inglês
出版: 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035745/
https://ncbi.nlm.nih.gov/pubmed/28061688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010716-104558
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