Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2

Angiopoietin-2 (Ang2) appears to be a naturally occurring antagonist of the endothelial receptor tyrosine kinase Tie2, an important regulator of vascular stability. Destabilization of the endothelium by Ang2 is believed to potentiate the actions of proangiogenic growth factors. To investigate the sp...

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Autores principales: White, Rebekah R., Shan, Siqing, Rusconi, Christopher P., Shetty, Geetha, Dewhirst, Mark W., Kontos, Christopher D., Sullenger, Bruce A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC154292/
https://ncbi.nlm.nih.gov/pubmed/12692304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0831159100
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