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Dominant Negative Effects of a Non-conducting TREK1 Splice Variant Expressed in Brain
Two-pore domain potassium (K(2P)) channels modulate neuronal excitability throughout the entire CNS. The stretch-activated channel TREK1 (K(2P)2.1) is expressed widely in brain and has been linked to depression, neuroprotection, pain perception, and epilepsy. Little, however, is known about the regu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937962/ https://ncbi.nlm.nih.gov/pubmed/20605797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108423 |
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